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It is recommended that if Casodex is started in patients already receiving coumarin anticoagulants, prothrombin times should be closely monitored and adjustment of the anticoagulant dose may be necessary (see CLINICAL PHARMACOLOGY, Drug-Drug Interactions). Clinical studies have shown that with co-administration of Casodex, mean midazolam (a CYP 3A4 substrate) levels may be increased 1. 71) higher in the Casodex group and in the smaller trial (N=140), the risk of death was 36% (HR 0. Casodex is given as part of a combination prostate cancer treatment with another medication that prevents the testicles from producing testosterone. coli, CHO/HGPRT, human lymphocyte cytogenetic, mouse micronucleus, and rat bone marrow cytogenetic tests) has demonstrated that Casodex does not have genotoxic activity.
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